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HISTORY
JOHNE'S INFORMATION CENTER - University of Wisconsin Ñ School of Veterinary Medicine
University of Wisconsin - School of Veterinary MedicineUniversity of Wisconsin - School of Veterinary Medicine
GALLERY GRAPHICS



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Photo of Enlarged mesenteric lymph nodes
Enlarged mesenteric lymph nodes
Johne’s disease frequently causes lymph nodes near the intestine to become enlarged (arrow).
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Photo of Thick, corrugated mucosal surface of the ileum Thick, corrugated mucosal surface of the ileum
The classical pathology of Johne’s disease in cattle, visible to the naked eye, is a thickened ileum. The extensively folded inner, mucosal, surface looks like corrugated cardboard
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Photo of Acid_fast stain: ileum Acid_fast stain: ileum
Special stains, called acid-fast stains, can reveal the red, rod-shaped mycobacteria in the intestinal tissue. They are clustered inside white blood cells.
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Photo of AGID blood test for Johne’s disease AGID blood test for Johne’s disease
AGID test, sold under the trade name Rapid Johne’s Test, is a simple, easy to perform test for Johne’s disease that can be used on cattle with clinical signs; diarrhea and weight loss.
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Photo of Lymphangitis in a bovine ileum Lymphangitis in a bovine ileum
Outside surface of a bovine ileum infected with M. paratuberculosis. The white line (arrow) indicates inflamed and dilated lymphatics: pathology indicative of Johne’s disease in cattle.
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Photo if diarrhea in cow Diarrhea: an early sign of Johne's disease in cattle
Many factors affect the consistency of cattle manure, however, loose manure to watery diarrhea are clinical signs consistent with Johne’s disease.
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electron micrograph photo of M. Paratuberculosis bacteria Scanning electron micrograph of M. paratuberculosis
M. paratuberculosis magnified over 50,000 times as seen by an electron microscope.
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Photo of giant cell in ileum Giant cell in ileum
Giant cells in a acid-fast stained tissue section. Seeing such cells, along with acid-fast bacteria is diagnostic for paratuberculosis.
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Photo of histopathology of ileum Histopathology: ileum
A thin section of bovine intestine stained with H&E, among the most common stains. The normal architecture of the tissue is changed due to inflammation in response to the M. paratuberculosis infection.
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Photo of test tubes with standard culture Standard culture method
Herrold’s egg yolk agar is a culture medium widely used to grow M. paratuberculosis from clinical samples like feces. Growth of bacterial colonies on this medium containing mycobactin, and not on medium without mycobactin (right hand tube), is indicative of M. paratuberculosis.
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Photo of cow with bottle jaw Bottle jaw can be a sign of Johne's disease
Due to low levels of serum albumin caused by Johne’s disease some cattle develop this lump under the jaw called "bottle jaw".
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Portrait of Heinrich Albert Johne Heinrich Albert Johne
In 1895, this German physician, and his American colleague, Frothingham, were the first to describe the disease now known as bovine paratuberculosis.
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Photo of thickened intestinal mucosa Thickened intestinal mucosa due to Johne's disease
In cattle, infection of the intestine with M. paratuberculosis leads, over the course of several years, to marked thickening. This photos shows a normal (bottom) and affected bovine ileum.
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Photo of colonies of M. Paratuberculosis

Colonies of M. paratuberculosis
The colonial morphology of M. paratuberculosis is affected by the composition of the culture medium. This close up view of M. paratuberculosis colonies on Middlebrook agar medium shows the very rough colonial morphology typical of the organism grown in the absence of Tween.



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