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HISTORY
JOHNE'S INFORMATION CENTER - University of Wisconsin Ñ School of Veterinary Medicine



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Sunday, August 26, 2001
Crohn's: An autoimmune or bacterial-related disease? An article in The Scientist (volume 15, page 22, Aug. 20, 2001) concisely describes discovery that mutations in the NOD2 gene are associated with Crohn's disease in roughly 15% of patients. The article also outlines evidence for involvement of other genes in the pathogenesis of Crohn's disease such as those involving the major histocompatibility complex. It concludes by outlining the debate on M. paratuberculosis involvement in this disease and recent activities by the U.S. National Institutes of Health on this topic. (To access this site you will have to register. Registration is free of charge.)

View this article on The Scientist's
web site.