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JOHNE'S INFORMATION CENTER - University of Wisconsin Ñ School of Veterinary Medicine



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Thursday, January 11, 2018
REVIEW ARTICLE

Pathogenesis, Molecular Genetics, and Genomics of Mycobacterium avium subsp. paratuberculosis, the Etiologic Agent of Johne’s Disease

This excellent review article is a technical summary of what we know about MAP, mainly from the veterinary perspective. It highlights the fecal-oral method of primary transmission, and how MAP causes disease in animals by increasing intestinal permeability and infecting macrophages, which results in granulomas. Diagnostics and current vaccines are discussed, with the caveat that none provide long term immunity. Zoonotic potential is outlined, with a quick overview of published research, and the mapping of the MAP K-10 genome is presented. The article concludes with an in depth discussion of potential vaccines in development and states that live-attenuated vaccines are the best approach against mycobacteria.

This article is available in full on the Frontiers in Veterinary Science journal.