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JOHNE'S INFORMATION CENTER - University of Wisconsin Ñ School of Veterinary Medicine
JOHNE'S INFORMATION CENTER - University of Wisconsin - School of Veterinary Medicine




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Monday, November 28, 2016
Paratuberculosis: Past, present and future.

Publication

This document provides the text of a keynote speech delivered by M.T. Collins at the 2016 World Buiatrics Congress (July, 2016 in Dublin, Ireland). The speech looks back on the 100+ year history of paratuberculosis, assesses the status of the disease today, makes predictions about the future of this disease, and offers six bullet points on the way forward.

The views and opinions expressed in this speech are those of the author alone.

Full text of WBC speech


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Tuesday, November 8, 2016
Anti-MAP therapy cures Crohn's disease: Case report

Publication

Examination of samples of stool from a 61-year-old male patient, presenting with the clinical symptoms of Crohnís disease (CD), revealed massive shedding of acid fast bacilli with the morphology of Mycobacterium avium paratuberculosis (MAP), the causative agent of Johneís disease in cattle. MAP was cultured from the stool. Biotyping of the bacterium isolated from cultures of stool demonstrated, it was the Indian Bison biotype of MAP, the dominant biotype infecting livestock and humans in India. Based on this finding and because the patient was unresponsive to standard therapy used in India to treat patients with gastrointestinal inflammatory disorders, the patient was placed on a regimen of multi-antibiotic therapy, currently used to treat tuberculosis and CD. After 1 year of treatment, the patientís health was restored, concurrent with cessation of shedding of MAP in his stool. This patient is the first case shown to shed MAP from the stool who was cured of infection with antibiotics and who was concurrently cured of clinical signs of CD.

Link to Frontiers in Medicine article


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Monday, July 25, 2016
Review Article: The zoonotic potential of Mycobacterium avium ssp. paratuberculosis: a systematic review and meta-analyses of the evidence.

Publication

This is the fourth such major literature review and the fourth to verify a consistent association of MAP and Crohnís disease. The article also concludes there is an association of MAP and multiple sclerosis (MS). However, the authorsí are very cautious in their assessment of what actions should be taken as shown by this excerpt of their publication's concluding paragraph:



Although we presented some strong and consistent MA [meta-analysis] results of the association between M. paratuberculosis and human disease; the variability in M. paratuberculosis prevalence in controls and diseased groups and a lack of understanding whether some or all CD [Crohnís disease] is caused or propagated by M. paratuberculosis are important knowledge gaps. These are the reasons for the lack of support for recommending further interventions against human exposure to M. paratuberculosis beyond what the dairy and ruminant industries have already developed for animal health and economic reasons. Thus, M. paratuberculosis may have a role in human disease; however the evidence is not strong enough to inform the potential public health impact of M. paratuberculosis exposure.

PubMed Link


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