University of Wisconsin–Madison


Johne’s disease can be controlled in sheep flocks. Find the infection as soon as possible, keep good records, and make sure that lambs have no chance to swallow MAP-contaminated milk, colostrum, hay or water.

Control is easy, it just takes time.


Johne’s disease can be controlled and even completely eliminated from infected herds. However, it takes a thorough understanding of the disease by animal owners, consultation with a veterinarian, and requires use of the available diagnostic tests. Half-hearted attempts to control Johne’s disease will generally fail. Control of Johne’s disease also takes time and a strong commitment to management practices focused on keeping young lambs away from contaminated manure, milk, water, etc. A typical flock clean-up program may take a number of years. Faster clean-up programs are possible, but they are usually more expensive. Emotional attachment to animals often prevents culling aanila in a timely manner which only delays or makes worse the Johne’s disease problem.

The basics of control are simple: new infections must be prevented, and animals with the infection must be identified and removed from the herd.

#1 Prevent new infections in lambs

Manure management

The most MAP bacteria excreted by infected sheep are in the feces (manure). Farm sanitation and control over where manure goes on a farm are critical to control of Johne’s disease. Because of the susceptibility of lambs to MAP infection, it is important to keep them well away from feces from adult sheep that may harbor the infection, at least for the first 6 months of life, the “window” of maximum susceptibility.

Lambs should be born in a clean dry environment with minimal fecal contamination. Individual lambing pens are optimal but if not feasible, you may establish test-negative and test-positive pens (you could test all your sheep a few months before lambing season to have the results available before at the right time). Then try to establish an area outside the pen free of adult manure contamination (“the safe zone”) for lambs born to test-negative ewes.


Manure contamination of water supplies, particularly ponds or streams that lambs can drink from, must be avoided to limit spread of the infection. If you use water troughs, when cleaning them remove the sediment at the bottom and dump it away from where animals might graze – MAP apparently survives for a long time in this wet mud.

Pasture contamination with MAP is also important as a means of infection transmission, but it is less important than other modes of transmission and far more difficult to control. For the very concerned, you can till contaminated pastures and wait for time and environmental conditions (repeated changes in temperature, minimize shaded soil by cutting grass/crops/shrubs) to kill off MAP on fields. While a majority of the organisms die within three months, a small population can remain for up to a year. Put off stocking contaminated pasture with young animals as long as feasible.

Read about survival of MAP in the environment in the “Biology of MAP” section of this site.

Milk and colostrum management

Many animals infected with MAP will excrete the bacterium in their milk. This happens most often in ewes showing clinical signs of Johne’s disease, but also occurs in infected animals that appear healthy.

A safe and effective alternative to milk replacers is to pasteurize milk on the farm. A recent study saw no difference in the number of new cases of Johne’s disease arising in dairy herds (cattle) between those that pasteurized and those that used milk replacer (Recommended protocols: 145°F (63°C) for 30 minutes for batch pasteurization, or 162°F (72°C) for 15 seconds for flash pasteurization. The milk should be stirred or otherwise in motion to ensure even heat distribution.) Pasteurization kills virtually all MAP that may contaminate raw milk as well as other viral and bacterial agents that could affect the health of replacement animals.

Colostrum, the antibody-rich milk produced by sheep in the first few days after giving birth, also can contain MAP. Because colostrum is critical to the health and survival of newborns, feeding colostrum must be done. Many farms do not collect and store colostrum sufficiently carefully to minimize contamination if they choose to bottle-feed lambs. However, the risk of transmitting MAP infections in colostrum can be minimized by following these three simple rules:

  • Use colostrum from Johne’s test-negative animals only.
  • Do not pool colostrum from multiple animals.
  • Thoroughly wash and dry the udder and teats before collection of aseptic collection of colostrum into clean containers.

Pasteurization of colostrum is technically a fourth alternative. However, the thick viscous nature of colostrum makes it very difficult to pasteurize and so for practical reasons it is not advised.

#2 Identify and remove infected adult sheep

Test-and-cull program

The majority of MAP infections in a flock are “invisible”. Sheep with clinical signs of Johne’s disease (primarily weight loss) are only a small fraction of the infected sheep in a flock. The infection has the ability to silently spread from ewes to lambs long before signs of illness in MAP-infected animals are evident. For this reason, laboratory tests are important to determine which sheep are infected. Test-positive sheep are generally those most likely to be infectious (excreting MAP in milk and manure) and so they should be removed, or at least isolated from, the herd.

Referred to as a test-and-cull program, this practice is essential to successful control of Johne’s disease in flocks in a reasonable period of time. Clearly, there are situations where alternatives must be considered: testing and culling of all test-positive animals is not necessarily always required. For instance, some control programs retain sheep with low or medium-level ELISA results to generate income but these sheep are clearly tagged, strictly managed since they are almost certainly shedding MAP on the premises in their manure as well as in their milk, and culled from the flock as soon as economically feasible. Farmers report that knowing the Johne’s test status of a sheep affects when the it is culled if she develops any other health problems. Decisions on how best to implement testing in a Johne’s control program should be made in consultation with your veterinarian. For details about available laboratory tests for Johne’s disease, see the goat diagnosis section of this web site.


MAP is resistant to most disinfectants; washable tools, troughs, and feed dishes may be treated as directed on the bottle with a disinfectant labeled as “tuberculocidal”. Since organic material deactivates the disinfectant, items should thoroughly cleaned with soap and water, rinsed and dried before the disinfectant is applied. Tuberculocidal disinfectants usually contain strong chemical compounds and should be used carefully. The instructions provided on the label for proper use and safe handling should be followed precisely.


No Johne’s disease vaccines are available for sheep in the United States. In Europe and Australia a vaccine (Gudair) is used in small ruminants and has been found to decrease the frequency of sheep that develop clinical Johne’s disease and reduces the amount of shedding of MAP. It does not appear to change the rate at which sheep become infected.

Considerable research is ongoing to devise better and safer vaccines for Johne’s disease.