University of Wisconsin–Madison


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What is Johne's disease and what causes it?

Johne’s (pronounced “Yoh-nees”) disease and paratuberculosis are two names for the same animal disease. Named after a German veterinarian, this fatal gastrointestinal disease was first clearly described in a dairy cow in 1895.

Scanning electron micrograph of a single MAP cell

A bacterium named Mycobacterium avium subspecies paratuberculosis (abbreviated “MAP”) is the cause of Johne’s disease. The infection happens in the first few months of a goat’s life but the animal may stay healthy for a very long time. Symptoms of disease may not show up for many months to years after the infection starts. This period of time is called the “incubation period”. MAP infections are contagious, which means it can spread from one goat to another, and from one species to another (cows to goats, goats to sheep, etc.).

MAP is very hardy – while it cannot replicate outside of an infected animal, it is resistant to heat, cold and drying. See “Biology of MAP” for more information about this bacterial pathogen.

What kind of animals get Johne's disease?

Ruminants susceptible to MAP

Johne’s disease is primarily a health problem for ruminant species (ruminants are hoofed mammals that chew their cud and have a 3-4 chambered stomach) and occurs most frequently in domestic agriculture herds. Some of the more common ruminants are cattle, sheep, goats, deer, and bison. It is particularly common in dairy cattle, not because they are more susceptible to infection but because they are more frequently exposed to the organism that causes Johne’s disease (MAP). Infected ruminants have been reported from all parts of the world. Non-ruminants such as omnivores or carnivores (birds, raccoons, fox, mice, etc.) may become infected, but rarely do they become sick because of the infection.

What are the symptoms of Johne's disease and what causes them?

Dairy goat with clinical Johne’s disease.

There really are only two clinical signs of Johne’s disease: rapid weight loss and diarrhea. In goats, diarrhea is less common than in cattle. The MAP infection occurs in kids in the first months of life, but signs of disease usually do not appear until the animals are adults. Despite continuing to eat well, adult goats become emaciated and weak. Since the signs of Johne’s disease are similar to those for several other diseases, laboratory tests are needed to confirm a diagnosis. If a case of Johne’s disease occurs, it is very likely that other MAP-infected goats, that may still appear healthy but are incubating the infection, are in the herd.


Diagram of the intestinal pathology resulting from a MAP infection of the small intestine. The granulomatous inflammation leads to intestinal thickening and malabsorption as evidenced by diarrhea and weight loss.

No one yet understands what causes a clinically normal goat that has been infected by MAP for months or years to suddenly become sick from the infection.We do know that at some point the MAP that have been lying quietly within cells of the last section of the small intestine (called the ileum) start to replicate and take over more and more of the tissue. The animal’s immune system responds to all these organisms with what is called granulomatous inflammation. This inflammation thickens the intestinal wall, preventing it from functioning normally. This, among other factors, means the animal cannot absorb the nutrition it needs and thus begins to lose body condition, milk production drops off, and diarrhea may occur. In effect, an animal with Johne’s disease is starving in spite of having a good appetite and eating well.

How common is Johne's disease?

Every country that has tested their ruminant domestic agriculture species for Johne’s disease has found cases of infection. The infection is much more prevalent in captive ruminants than in free-ranging ruminants such as deer or elk. No one knows the number of infected goat herds in the United States due to lack of testing and reporting. Cases have occurred in many breeds, in milk goats, in meat goats, in 4H herds, etc. It is a common problem in countries with a significant size small ruminant industries, such as Spain and Australia.

How do goats get infected?

Goat kids drinking pooled milk.

Johne’s disease typically enters a herd when a MAP-infected, but healthy-looking, goat is purchased. This infected goat then sheds MAP in its feces onto the premises – perhaps onto pasture or into water shared by its new herdmates. Young animals are far more susceptible to infection than are adults: these kids swallow the organism along with grass or water. Perhaps they are bottle-fed with MAP-contaminated milk collected from the infected but healthy-appearing new arrival. Milk may become contaminated from the environment (manure-stained teats) or, in the advanced stages of the infection, the bacterium is shed directly into the milk. Animals may even have been infected before they are born, called in utero transmission, if the doe is in advanced stages of the MAP infection. Thus the infection spreads insidiously, without the owner’s being aware of it.

How can you protect your herd from Johne's disease?

Do not introduce it!

Try to purchase animals from a source herd free of Johne’s disease. Second best is to work with producer who knows the level of Johne’s disease in his or her herd, follows good infection control practices, and then purchase test-negative animals from test-negative dams. Remember that Johne’s disease is a herd problem, and that knowing the test-status of numerous adults in the source herd will give you a much better sense of the risk of purchasing an infected animal than the one test result you might get on the single goat you wish to buy. Evaluating a source herd is not always easy but keeping the infection out of your herd is much less costly and troublesome than controlling it once it gets into a herd. Laboratory tests are available for all animal species.

After a new animal comes to your farm, it is advisable to repeat diagnostic tests while the animal is held in quarantine – safely separated from the rest of the herd.

How do you test goats for Johne's disease?

New approaches are now available for testing that are cheaper and more reliable than ever before. The two common ways to test a herd for Johne’s disease are: direct PCR on fecal samples (the most accurate, but most expensive method), and  tests on blood or milk samples for antibodies made by the animal in response to MAP infection.

There are many good testing strategies to choose from – more detailed diagnostic testing information can be found by selecting “Diagnosis” under “Goat” as the animal species of interest in the main menu bar.

How do you control Johne's disease in a goat herd?

Young goat drinking from a bottle.

The best methods for MAP infection control in your goat herd depend on the resources available, the goals of your enterprise, and the methods you use to take care of your goats. All control methods however rely on two core strategies that must be employed at the same time:

  1. Kids must be protected from infection by being born and raised in a clean environment and fed milk and water free of MAP contamination. The primary sources of MAP contamination are manure and/or milk from infected adult animals.
  2. Adult animals infected with MAP must be identified and culled managed to ensure no kids are exposed to their milk or manure. Because twins are common for goats, the annual risk of a new case born to an infected doe is believed to be twice the risk seen in species that produce just one offspring a year.

No vaccines are available in the United States for Johne’s disease in goats, however, in Spain, Australia and several other countries vaccines are used.

Can Johne's disease be cured with antibiotics?

No. In the few studies that attempted to treat Johne’s disease with antibiotics in cattle, symptoms appeared to subside but animals relapsed after therapy was halted. As with other mycobacterial infections (for instance, human tuberculosis) multiple antibiotics must be injected or given orally daily for months. For most animals, this is cost-prohibitive as well as infeasible. For more detailed information visit the page on “Antimicrobial Therapy”.

Can humans get Johne's disease?

The term “Johne’s disease” is used only to describe the clinical illness in ruminants that occurs after MAP infection.

There is a human ailment however called “Crohn’s disease” that in several ways resembles Johne’s disease. Crohn’s disease is a chronic inflammatory bowel disease (IBD) that has no known cause and no known cure. In some studies MAP has been found in tissues of Crohn’s disease patients more often than controls. Some researchers believe MAP contributes to Crohn’s disease for at least a subset of patients. The majority of gastroenterologists, however, do not; they believe that MAP, if found in this subset of patients, is simply a by-stander amongst the many other organisms that are found in a malfunctioning gastrointestinal tract. No connection has been shown between contact with animals with Johne’s disease, dairy product or meat consumption and Crohn’s disease. This aspect of MAP is a complex and controversial area of scientific investigation. A detailed discussion of this topic can be found on the “Zoonotic Potential” page of this website.